文献类型：期刊文献

中文题名：1-丙二烯基-2,3,4,6-四-氧-乙酰基-β-D-吡喃糖苷的合成及反应机理

英文题名：Synthesis of 2,3,4,6-tetra-O-acetyl-1-allylidiene-β-D-glycosides and Its Elimination Reaction Mechanism

作者：陈国荣[1];黄小婷[1];饶刚[1];陈孔常[1];谢毓元[2]

机构：[1]华东理工大学精细化工研究所,上海200237;[2]中国科学院上海药物研究所,上海200031

年份：2001

卷号：27

期号：4

起止页码：411

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金资助项目 (2 97760 13 )

语种：中文

中文关键词：合成方法;消除反应;体外免疫调节;1-丙二烯基-2,3,4,6-四-氧-乙酰基-β-D-吡喃糖苷;反应机理

外文关键词：glycosides; synthetic methods; elimination reaction; in vitro immunological adjustment

摘要：分别采用化学、声化学及光辐射等方法合成了 1 -丙二烯基 - 2 ,3,4,6-四 -氧 -乙酰基 - β- D-吡喃糖苷 ,结果表明声化学方法最有效、快速 ;借助电子自旋共振 ( ESR)技术及相关实验 ,证实此类糖苷的生成为一离子消除反应 ;所合成的糖苷化合物脱去乙酰基后对 T。
Tetra O acetyl 1 allylidiene D glycosides were synthesized by chemical, ultrasonic chemical and photochemical methods respectively and the results showed ultrasonic method was the most efficient one. ESR technique and correspondent experiments proved that the reaction to produce this kind of glycosides was an ionic elimination reation. The deacetylated products were tested for their pharmacological activity and were found having in vitro immunological adjustment effect on T,B lymphocyte.