文献类型：期刊文献

英文题名：Quaternary Ammonium Groups Modified Starch Microspheres for Instant Hemorrhage Control

作者：Chen, Fangping[1,2,3];Cao, Xiaoyan[3];Yu, Junxia[3];Su, Huantong[3];Wei, Shuda[2,3];Hong, Hua[2,3];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2017

卷号：159

起止页码：937

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20173704158695);WOS:【SCI-EXPANDED(收录号:WOS:000418729600107)】；

基金：This investigation was supported by National Key Research and Development Program of China (No.2016YFC1102900), National Natural Science Foundation of China (No.31370960, 51772100), Shanghai Pujiang Program(16PJD015), National Economic Mobilization Project(D800-G-35) and the 111 Project (B14018).

语种：英文

外文关键词：Microsphers; Quaternary ammonium; Hemostatic

摘要：Instant rapid hemostasis is crucial not only for decreasing mortality in these conditions, but also for optimal recovery. The hemostatic agents on the market suffer from inefficiency hemostasis, nondegradability, high cost and potential safety issues. It is necessary to develop a hemostatic agent with rapid hemostatic performance, potent biodegradation and improved biocompatibility. The aim of this work was to develop a novel type of cationic modified starch microspheres (CS) and investigate its hemostatic performance. CS was firstly developed via enzymatic hydrolysis and then assembled with quaternary ammonium groups by etherification reaction with microsporous starch. The result showed that CH3-N+ groups were successfully grafted on the backbone of CS. The zeta potential of CS was increased by 19 my and the viscosity was improved with a tenfold. Rapid water absorption ratio (304.2%, only 81.8% of pure Starch) and high swelling capacity of CS (1008%, nearly quadruple higher than pure Starch), together with its porous structure, enhanced the physical hemostatic efficacy. In addition, in vitro coagulation studies showed that CS induced the adhesion of red blood cell and platelet, and thus activated the blood chemical coagulation system due to the positive charge. In vivo studies in rabbit liver injuries model further confirmed the dramatic improvement in the hemostatic capacity of CS because the synergistic effects of the chemical activation mechanism and physical absorption mechanism. Furthermore, the degradation of CS was greatly improved by the modification. This study suggested the quaternary ammonium groups modified starch microspheres could serve as an effective and promising hemostatic agent for instant rapid hemostasis. (C) 2017 Elsevier B.V. All rights reserved.