文献类型：期刊文献

英文题名：3D Embedded Printing of Complex Biological Structures with Supporting Bath of Pluronic F-127

作者：Hu, Tianzhou[1,2];Cai, Zhengwei[3];Yin, Ruixue[1];Zhang, Wenjun[2];Bao, Chunyan[3];Zhu, Linyong[3];Zhang, Honbo[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200231, Peoples R China;[2]Univ Saskatchewan, Dept Biomed Engn, Saskatoon, SK S7N 5A2, Canada;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200231, Peoples R China

年份：2023

卷号：15

期号：17

外文期刊名：POLYMERS

收录：;EI(收录号：20233714718030);WOS:【SCI-EXPANDED(收录号:WOS:001062569000001)】；

语种：英文

外文关键词：3D printing; supporting bath; hydrogel; biological structure

摘要：Biofabrication is crucial in contemporary tissue engineering. The primary challenge in biofabrication lies in achieving simultaneous replication of both external organ geometries and internal structures. Particularly for organs with high oxygen demand, the incorporation of a vascular network, which is usually intricate, is crucial to enhance tissue viability, which is still a difficulty in current biofabrication technology. In this study, we address this problem by introducing an innovative three-dimensional (3D) printing strategy using a thermo-reversible supporting bath which can be easily removed by decreasing the temperature. This technology is capable of printing hydrated materials with diverse crosslinked mechanisms, encompassing gelatin, hyaluronate, Pluronic F-127, and alginate. Furthermore, the technology can replicate the external geometry of native tissues and organs from computed tomography data. The work also demonstrates the capability to print lines around 10 & mu;m with a nozzle with a diameter of 60 & mu;m due to the extra force exerted by the supporting bath, by which the line size was largely reduced, and this technique can be used to fabricate intricate capillary networks.