文献类型：期刊文献

英文题名：Effect of mycelial morphology on bioreactor performance and avermectin production of Streptomyces avermitilis in submerged cultivations

作者：Yin, Peng[1];Wang, Yono-Hong[1];Zhang, Si-Liang[1];Chu, Ju[1];Zhuang, Ying-Ping[1];Chen, Ning[1];Li, Xin-Feng[1];Wu, Yan-Bin[1]

机构：[1]E China Univ Sci & Technol, Natl Res Ctr Biotechnol Shanghai, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2008

卷号：39

期号：6

起止页码：609

外文期刊名：JOURNAL OF THE CHINESE INSTITUTE OF CHEMICAL ENGINEERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000260915800008)】；

基金：The financial support from the National Natural Science Foundation of China (20476028) and National Basic Research Program (973 program no. 2007CB714303) are gratefully acknowledged.

语种：英文

外文关键词：Avermectin; Image; Morphology; Pellet; Streptomyces avermitilis

摘要：Factors affecting the morphology of Streptomyces avermitilis and avermectin production in submerged cultivation, including nitrogen sources, inoculum level and DO (dissolved oxygen) tension in the broth were investigated in a 50-L bioreactor. It was found that a combination of soybean meal and yeast meal as nitrogen sources and 4.3% inoculum led to pellet formation, and the pellet morphology facilitated to maintain DO > 20% in the early stage of fermentation. With the aid of image analysis tools, area and density of pellets in different batches were calculated. Results show that higher dissolved oxygen tension was favorable for pellet formation and avermectin production. (C) 2008 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.