文献类型：期刊文献

英文题名：Pd-catalyzed direct oxidative mono-aroyloxylation of O-aralkyl substituted acetoxime ethers

作者：Shao, Ling-Yan[1];Li, Chao[1,2];Guo, Ying[1];Yu, Kun-Kun[1];Zhao, Fei-Yi[1];Qiao, Wen-Li[1];Liu, Hong-Wei[1];Liao, Dao-Hua[1];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Roche R&D Ctr China Ltd, 720 Cailun Rd, Shanghai 201203, Peoples R China

年份：2016

卷号：6

期号：82

起止页码：78875

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20163602774612);WOS:【SCI-EXPANDED(收录号:WOS:000382539300077)】；

基金：We gratefully thank the National Natural Science Foundation of China (Project No. 21176074 and 21476074) and Research Fund for the Doctoral Program of Higher Education of China (Project No. 20130074110009) for financial support.

语种：英文

外文关键词：Aromatic compounds - Catalysis - Organometallics

摘要：A highly site-selective palladium-catalyzed ortho-mono-aroyloxylation of O-aralkyl substituted acetoxime ethers via direct Csp(2)-H bond activation has been developed with simple exo-acetoxime as a directing group. The broad scope of masked aralkylalcohols and various aromatic acid partners are compatible with this transformation, which should undergo a mechanistic pathway of six, seven, or even eight-membered exo-cyclopalladated intermediates. In addition, the acetoxime directing group can be readily removed through N-O bond selective cleavage at a late stage, providing a potential utility for the preparation of valuable functionalized aromatic alcohols.