文献类型：期刊文献

英文题名：A general strategy for construction of a difluoromethyl compound library and its application in synthesis of pseudopeptides bearing a terminal difluoromethyl group

作者：Wu, Jingjing[1];Cao, Song[1];Liu, Nianjin[1];Shen, Li[1];Yu, Jinlong[1];Zhang, Jian[1];Li, Hui[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Ctr Fluorine Chem Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2010

卷号：8

期号：10

起止页码：2386

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20102012938470);WOS:【SCI-EXPANDED(收录号:WOS:000277399300014)，CCR-EXPANDED(收录号:WOS:000277399300014)】；

基金：We are grateful for financial supports from the National Basic Research Program of China (973 Program, 2010CB126101), Shanghai Foundation of Science of Technology (09391911800), the National High Technology Research and Development Program of China (863 Program, 2006AA10A201), and the Shanghai Leading Academic Discipline Project (B507).

语种：英文

摘要：We describe the development of a novel synthesis strategy that uses common reaction conditions to transform a collection of simple building blocks into complex molecules bearing a terminal difluoromethyl group. The core of this approach is the conscious design and synthesis of new difluorinated building blocks which contain inactive and reactive groups on each side of the CF(2) group. The strategy is illustrated by application to the synthesis of CF(2)H-bearing pseudopeptides via Ugi reaction.