文献类型：期刊文献

英文题名：A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout

作者：Xu, Hang[1,2];Ma, Shengnan[1,2];Liu, Qianqian[1,2];Huang, Lixian[1,2];Wu, Peimin[1,2];Liu, Xiaolin[1,2];Huang, Yali[1,2];Wang, Xiaolei[1,2];Xu, Huan[1,2];Lou, Kaiyan[1,2];Wang, Wei[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA;[4]Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA

年份：2019

卷号：55

期号：49

起止页码：7053

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000471721700012)】；

基金：The work was supported by the National Natural Science Foundation of China (Grant No. 21577037, K. L. and 21738002, W. W.), the State Key Laboratory of Bioengineering Reactor (W. W.), and Shanghai Sailing Program (Grant No. 19YF1412500, H. X.).

语种：英文

摘要：A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.