文献类型：期刊文献

英文题名：Palladium-Catalyzed Transfer Hydrogenation and Acetylation of N -Heteroarenes with Sodium Hydride as the Reductant

作者：Luo, Fan[1,2,3];Chen, Xiaobei[1,2];Yu, Jing[3];Yin, Yuejia[3];Hu, Xiaoxiao[3];Hu, Ying[4];Liu, Xuejun[5];Chen, Xiaodong[5];Zhang, Shilei[3];Hu, Yanwei[3]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China;[3]Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[4]Suzhou Vocat Hlth Coll, Dept Pharm, 28 Kehua Rd, Suzhou 215009, Peoples R China;[5]Shanghai Neutan Pharmaceut Co Ltd, Bldg 26,555 Huanqiao Rd,Pudong New Area, Shanghai 201315, Peoples R China

年份：2023

卷号：55

期号：09

起止页码：1451

外文期刊名：SYNTHESIS-STUTTGART

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000906995500001)】；

基金：This work was supported by the National Natural Science Foundation of China (22271206 and 22071053), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), East China University of Science and Technology, the `111' Project and PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).

语种：英文

外文关键词：palladium; sodium hydride; transfer hydrogenation; N -heteroarenes; N -heterocycles

摘要：An efficient and convenient palladium-catalyzed reductive system by employing sodium hydride as the hydrogen donor and acetic anhydride as an activator has been developed for transfer hydrogenation and acetylation of a wide range of N-heteroarenes including quinoline, phthalazine, quinoxaline, phenazine, phenanthridine, and indole. Moreover, acridine substrates could be directly reduced without the use of acetic anhydride. This protocol provides a simple method for the preparation of various saturated N-heterocycles.