文献类型：期刊文献

中文题名：非溶出抗菌聚乙烯醇/聚己基胍盐酸盐水凝胶及其增强

英文题名：Enhancement of Nonleaching Antimicrobial Poly(vinyl alcohol)/Poly(hexamethylene guanidine)Hydrogels

作者：贡吴玲[1];危大福[1];张韶天[1];叶晶蕴[1];郑安呐[1];管涌[1]

机构：[1]上海市先进聚合物材料重点实验室华东理工大学材料科学与工程学院,上海200237

年份：2020

卷号：51

期号：12

起止页码：1347

中文期刊名：高分子学报

外文期刊名：Acta Polymerica Sinica

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000589912700005)】；北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：上海市重点实验室项目(项目号ZD20170203)资助.

语种：中文

中文关键词：聚乙烯醇水凝胶;氢键;抗菌;增强

外文关键词：PVA hydrogel;Hydrogen-bond;Antimicrobial performance;Enhancement

摘要：通过冻融法制备了非溶出型的抗菌聚乙烯醇/聚己基胍盐酸盐(PVA/PHMG)水凝胶.傅里叶红外光谱测试结果表明:PHMG的胺基与PVA的羟基之间存在明显的氢键作用,这种作用赋予了PHMG非溶出性.PVA/PHMG水凝胶有非常优异的抗菌效果,并且拉伸强度为PVA水凝胶的2.2倍.进一步分别以氧化石墨烯(GO)和二氧化硅(SiO2)为增强剂,制备了PVA/PHMG/GO水凝胶和PVA/PHMG/SiO2水凝胶.2种复合水凝胶同样显示非溶出性抗菌性能;抗菌率在99.99%以上,水洗或在水中浸泡7天后抗菌率未降低.GO、SiO2与PVA/PHMG形成氢键,显著增强了水凝胶的拉伸强度.PVA/PHMG/GO和PVA/PHMG/SiO2水凝胶的拉伸强度分别是PVA/PHMG水凝胶的1.6倍和3.3倍.
A novel nonleaching antimicrobial poly(vinyl alcohol)/poly(hexamethylene guanidine)hydrochloride(PVA/PHMG)hydrogel was prepared with freezing-thawing method.The hydrogen bond interaction between PVA and PHMG confirmed by ATR-FTIR spectra,endowed PVA/PHMG hydrogels with the nonleaching characteristic.These antimicrobial hydrogels behaved above 99.9%of antimicrobial rates against both E.coli and S.aureus,even after washing or soaking in water for 7 days.The PVA-0.100wt%PHMG hydrogel had 120%higher tensile strength than pure PVA hydrogel due to the reinforement of hydrogen bonding between PVA and PHMG.Furthermore,GO(graphene oxide)and SiO2 were respectively added to the PVA-0.100wt%PHMG system to reinforce the mechanical properties.PVA/PHMG/GO hydrogel and PVA/PHMG/SiO2 hydrogel were also prepared via freezing-thawing method.These two composite hydrogels still showed nonleaching antimicrobial properties and the antimicrobial rates were above 99.99%even after washing or soaking in water for 7 days.Compared with PVA/PHMG hydrogel,the―OH peak of the PVA/PHMG/SiO2 hydrogels in the infrared difference spectra shifted to the lower wavenumbers by 38 cm?1,while the―OH peak of the PVA/PHMG/GO hydrogels shifted by 23 cm?1.Therefore,the hydrogen bonding effect of SiO2 with PVA/PHMG might be stronger than that of GO.The hydrogen bond interactions among reinforcing agents,PVA and PHMG significantly enhanced the tensile strength of the hydrogel.The tensile strengths of PVA/PHMG/GO and PVA/PHMG/SiO2 hydrogels were 1.6 times and 3.3 times of that of PVA/PHMG hydrogels,respectively.This study provides a simple approach to develop reinforced and nonleaching antimicrobial PVA hydrogels.