文献类型：期刊文献

英文题名：A ruthenium-nitrosyl-functionalized nanoplatform for the targeting of liver cancer cells and NIR-light-controlled delivery of nitric oxide combined with photothermal therapy

作者：Li, Yan-Hui[1];Guo, Min[1];Shi, Shu-Wen[1];Zhang, Qian-Ling[2];Yang, Shi-Ping[3,4];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China;[3]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2017

卷号：5

期号：38

起止页码：7831

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20174104249810);WOS:【SCI-EXPANDED(收录号:WOS:000412233000006)】；

基金：This study was financially supported by the National Nature Science Foundation of China (no. 21571062, 21271072 to JGL; 21471101, 21671137 to QLZ), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, Shenzhen Government's Plan of Science and Technology (JCY20150324140036843) to QLZ, and the Fundamental Research Funds for the Central Universities (no. 222201717003). We are grateful to Prof. Guorong Chen from East China University of Science and Technology for kindly providing us with the Gal compound.

语种：英文

外文关键词：Photodynamic therapy - Doping (additives) - Semiconductor quantum dots - Cells - Infrared devices - Biocompatibility - Ruthenium compounds - Cancer cells - Cell culture - Diseases

摘要：The development of light-controlled nitric oxide (NO)-releasing nanoplatforms that are capable of specifically targeting liver cancer cell lines and delivering an optimal amount of NO can significantly affect liver cancer therapy. In this study, a multifunctional nanoplatform {N-GQDs@Ru-NO@Gal} (1) for the near-infrared (NIR) light-responsive release of NO, consisting of a NO donor (Ru-NO) and a liver-targeting galactose derivative (Gal) covalently attached to N-doped graphene quantum dots (N-GQDs), was reported. Nanoplatform 1 preferentially targeted liver cancer cells over normal cells and instantly released NO as well as exhibited a prominent photothermal effect upon NIR irradiation at 808 nm, thereby leading to efficient anti-tumor efficacy. {N-GQDs@Ru-NO@Gal} with a small size (<10 nm), good biocompatibility, and fluorescent-tracing properties represents a unique example of a multifunctional NO-releasing nanoplatform that combines photodynamic and photothermal therapies for the targeted treatment of liver cancer. Hence, the developed nanoplatform demonstrates potential for applications in NO-mediated multimodal phototherapy in the near future.