文献类型：期刊文献

英文题名：NIR-Activated Polymeric Nanoplatform with Upper Critical Solution Temperature for Image-Guided Synergistic Photothermal Therapy and Chemotherapy

作者：Tian, Jia[1];Huang, Baoxuan[1];Li, Haiquan[1];Cao, Hongliang[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：20

期号：6

起止页码：2338

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20192106948379);WOS:【SCI-EXPANDED(收录号:WOS:000471212500017)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 51803058 and 21875063) and the Fundamental Research Funds for the Central Universities (no. 222201814018).

语种：英文

外文关键词：Targeted drug delivery - Synthesis (chemical) - Fluorescence imaging - Infrared devices - Block copolymers - Tumors - Controlled drug delivery

摘要：Premature and incomplete drug release is the typical bottleneck of drug release in traditional chemotherapy. Synergistic therapies are highly desirable in medicine and biology because they can compensate for the drawbacks of single therapy and significantly enhance the therapeutic efficacy. Herein, a novel near infrared (NIR)-activated polymeric nanoplatform with upper critical solution temperature (UCST) was constructed for image-guided synergistic photothermal therapy (PTT) and chemotherapy. UCST-responsive amphiphilic block copolymers were synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization and then co-assembled with IR780 and cabazitaxel (Cab) to form spherical nanoparticles (NPs). IR780/Cab dual-loaded UCST polymeric NPs can produce local heating upon NIR laser irradiation and further lead to the dissociation of cargo-loaded NPs and controlled release of Cab. IR780 plays the role of both a heating generator and an activator for "on-demand" drug release. The investigation of in vivo fluorescence and photothermal imaging clearly demonstrated tumor targeting. Notably, both in vitro and in vivo studies illustrated that the synergistic PTT and chemotherapy presented better anticancer efficacy than that of PTT and chemotherapy simplely combined. Thus, the well-defined polymeric nanoplatform opens a versatile and effective path to develop image-guided synergistic therapies for tumor treatment.