文献类型：期刊文献

英文题名：A DNA Nanodevice-Based Platform with Diverse Capabilities

作者：Li, Hua-Dong[1];Ma, Pei-Qiang[1];Wang, Jin-Yu[1];Yin, Bin-Cheng[1,2];Ye, Bang-Ce[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg Technol, State Key Lab Bioreactor Engn, Lab Biosyst & Microanal, Shanghai 200237, Peoples R China;[2]Zhejiang Univ Technol, Inst Engn Biol & Hlth, Coll Pharmaceut Sci, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Zhejiang, Peoples R China;[3]Shihezi Univ, Sch Chem & Chem Engn, Shihezi 832000, Xinjiang, Peoples R China

年份：2023

卷号：19

期号：37

外文期刊名：SMALL

收录：;EI(收录号：20231914065580);WOS:【SCI-EXPANDED(收录号:WOS:000980944700001)】；

基金：H.-D.L. and P.-Q.M. contributed equally to this work. This work was jointly supported by the National Natural Science Foundation of China (Grant Nos. 22134003, 21822402, and 22104037), "Shuguang Program" supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission (Grant No. 20SG26), and the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (Grant No. LHDMZ22H300008). The authors thank Prof. Yangyang Yang and Dr. Yue Liao (School of Pharmacy, East China University of Science and Technology) for their assistance with origami framework design and experimental guidance.

语种：英文

外文关键词：DNA nanodevices; molecular computing circuits; molecular recorder; signal transduction and feedback; virus variation and transmission simulation

摘要：Social biotic colonies often perform intricate tasks by interindividual communication and cooperation. Inspired by these biotic behaviors, a DNA nanodevice community is proposed as a universal and scalable platform. The modular nanodevice as the infrastructure of platform contains a DNA origami triangular prism framework and a hairpin-swing arm machinery core. By coding and decoding a signal domain on the shuttled output strand in different nanodevices, an orthogonal inter-nanodevice communication network is established to connect multi-nanodevices into a functional platform. The nanodevice platform enables implementation of diverse tasks, including signal cascading and feedback, molecular input recording, distributed logic computing, and modeling of simulation for virus transmission. The nanodevice platform with powerful compatibility and programmability presents an elegant example of the combination of the distributed operation of multiple devices and the complicated interdevice communication network, and may become a new generation of intelligent DNA nanosystems.