文献类型：期刊文献

英文题名：A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose

作者：Ruan, Jia-Li[1];Chen, Cheng[2];Shen, Jian-Hua[3];Zhao, Xue-Ling[2];Qian, Shao-Hong[1];Zhu, Zhi-Gang[2]

机构：[1]Fudan Univ, EENT Hosp, Dept Ophthalmol, Shanghai 200031, Peoples R China;[2]Shanghai Polytech Univ, Coll Engn, Sch Environm & Mat Engn, Shanghai 201209, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2017

卷号：9

期号：4

外文期刊名：POLYMERS

收录：;EI(收录号：20171503555559);WOS:【SCI-EXPANDED(收录号:WOS:000401719700011)】；

基金：This work was supported by the National Natural Science Foundation of China (61471233, 21504051, 21406072), the Program for Professor of Special Appointment (Eastern Scholar) at SIHL, the Sailing Project and Basic Research Program from the Science and Technology Commission of Shanghai Municipality (14YF1410600, 14JC1406402), Shuguang an Chenguang project supported by Shanghai Municipal Education Commission (14SG52, 14CG29), the international Science and Technology Cooperation Program of China (2015DFA31340), and Key Laboratory of Myopia from Fudan University, the key subject of Shanghai Polytechnic University (Material Science and Engineering, XXKZD1601). We thank Jian-Jiang Xu of EENT Hospital of Fudan University for providing us with HCECs. And we thank Chen Qiu and Gang Li of EENT Hospital of Fudan University for help revising the paper.

语种：英文

外文关键词：tear glucose; photonic crystal; contact lens; cytotoxicity; hydrogel; diffraction

摘要：Patients of diabetes mellitus urgently need noninvasive and continuous glucose monitoring in daily point-of-care. As the tear glucose concentration has a positive correlation with that in blood, the hydrogel colloidal crystal integrated into contact lens possesses promising potential for noninvasive monitoring of glucose in tears. This paper presents a new glucose-responsive sensor, which consists a crystalline colloidal array (CCA) embedded in hydrogel matrix, attached onto a rigid gas permeable (RGP) contact lens. This novel sensing lens is able to selectively diffract visible light, whose wavelength shifts between 567 and 468 nm according to the alternation of the glucose concentration between 0 and 50 mM and its visible color change between reddish yellow, green, and blue. The detection limit of responsive glucose concentration can be reduced to 0.05 mM. Its combination with a contact lens endows it with excellent biocompatibility and portability, which shows great possibility for it to push the development of glucose-detecting devices into new era.