文献类型：期刊文献

英文题名：High strength biocompatible PEG single-network hydrogels

作者：Qian, ShanShan[1];Zhou, Chao[1];Xu, Liqun[1];Yao, Fang[1];Cen, Lian[2,3];Fu, GuoDong[1]

机构：[1]Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[3]Natl Tissue Engn Ctr China, Shanghai 200241, Peoples R China

年份：2014

卷号：4

期号：48

起止页码：25241

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20142617861077);WOS:【SCI-EXPANDED(收录号:WOS:000338044500039)】；

基金：This work was supported by National Natural Science Foundation of China under the Grant 21274020, 21074022 and 21304019. This work was also supported by the Key Laboratory of Environmental Medicine Engineering of Ministry of Education (Southeast University) and National "973" Project Foundation of China (Grant no.: 2010CB944804).

语种：英文

外文关键词：Chains - Macromolecules - Biocompatibility - Copper compounds - Scaffolds - Biomedical equipment

摘要：In this work, PEG-based single-chain hydrogels with extremely high strength were successfully prepared via precise design and control over the molecular topology of the polymeric network. Initially, well-defined PEG macromolecules with uniformly dispersed pendant alkynyl groups (PEG(n)(C CH))(m) on their main chains were synthesized via amine-epoxy chain extension reaction of alpha,omega-diepoxy PEG and propargylamine. The subsequent copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) of (PEG(n)(C CH))(m) and alpha,omega-diazido PEG(n)(PEGn(N-3)(2)) gave rise to tough PEG-based hydrogels (Gel-PEG(n)(N-3)(2)-(PEG(n)(C CH))(m)). The lattice size of the Gel-PEGn(N-3)(2)-(PEG(n)(C CH))(m) networks can be tailored by varying chain lengths of PEG repeating segments in (PEG(n)(C CH))(m) and PEG(n)(N-3)(2). Different from traditional PEG hydrogels prepared by CuAAC, such as hydrogels from tetrakis(2-propynyloxymethyl)methane and PEG(n)(N-3)(2), the current novel hydrogels possess not only a high mechanical strength up to 62.5 MPa, but are also biodegradable favored by the presence of triethylamine groups in the (PEGn(C CH))(m) macromolecules. Furthermore, excellent biocompatibility of the Gel-PEG(n)(N-3)(2)-(PEG(n)(C CH))(m) was demonstrated according to the in vitro cytotoxicity assay. Hence, it can be ascertained that Gel-PEG(n)(N-3)(2)-(PEG(n)(C CH))(m) has promising potential for artificial medical devices or scaffolding materials for regenerative medicine.