文献类型：期刊文献

英文题名：Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

作者：Guo, Min[1];Xiang, Hui-Jing[1];Wang, Yi[2];Zhang, Qian-Ling[2];An, Lu[3,4];Yang, Shi-Ping[3,4];Ma, Yinchu[5,6];Wang, Yucai[5,6];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, MOE, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China;[3]Shanghai Normal Univ, MOE, Key Lab Resource Chem, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China;[5]Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Peoples R China;[6]Univ Sci & Technol China, Med Ctr, Hefei 230027, Peoples R China

年份：2017

卷号：53

期号：22

起止页码：3253

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000398998500022)】；

基金：This study was financially supported by the National Nature Science Foundation of China (no. 21271072, 21571062 to JGL; 21471101, 21671137 to QLZ), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, and Shenzhen Government's Plan of Science and Technology (JCY20150324140036843) to QLZ.

语种：英文

摘要：A mitochondria-targeting nanoplatform for near-infrared-light-controlled release of nitric oxide accompanied by photothermal therapy was developed, which consists of ruthenium nitrosyl functionalized N-doped graphene quantum dots and a triphenylphosphonium moiety. The nanoplatform demonstrated both in vitro and in vivo anti-tumor efficacy upon irradiation with 808 nm light.