文献类型：期刊文献

英文题名：cis-Configuration: A New Tactic/Rationale for Neonicotinoid Molecular Design

作者：Shao, Xusheng[1];Lee, Philip W.[1];Liu, Zewen[2];Xu, Xiaoyong[1];Li, Zhong[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Nanjing Agr Univ, Minist Agr, Key Lab Monitoring & Management Plant Dis & Insec, Nanjing 210095, Peoples R China

年份：2011

卷号：59

期号：7

起止页码：2943

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000289050400027)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2010CB126100, 2003CB114400) and the National High Technology Research and Development Program of China (863 Program, 2010AA10A204).

语种：英文

外文关键词：neonicotinoids; cis-configuration; insecticide; selectivity

摘要：Resistance development and limited lepidopteran activities call for the discovery of "super-neonicotinoids" solving these problems. Compounds with the cis-configuration offer an opportunity for further optimization. Fixing the nitro group in the cis-configuration provided a new approach for neonicotinoid molecular design. Introductions of the heterocycle or a bulky group are two synthesis concepts to fix the cis-configuration of the nitro group. The design, synthesis, bioactivity, and preliminary modes of action of five types of cis-neonicotinoids are reviewed. cis- and trans-Neonicotinoids have some differences in bioactivities and modes of action. This study focused, especially, on the reaction diversities of nitromethylene analogues of imidacloprid with various aldehydes.