文献类型：期刊文献

英文题名：Antibacterial activity of graphene supported FeAg bimetallic nanocomposites

作者：Ahmad, Ayyaz[1];Qureshi, Abdul Sattar[2];Li, Li[1];Bao, Jie[2];Jia, Xin[3];Xu, Yisheng[1];Guo, Xuhong[1,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Shihezi Univ, Dept Chem Engn, Xinjiang 832000, Peoples R China

年份：2016

卷号：143

起止页码：490

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20162802590066);WOS:【SCI-EXPANDED(收录号:WOS:000376696900058)】；

基金：We acknowledge the financial support from the National Natural Science Foundation of China (Nos. 51273063, 21476143, and 21306049), the Fundamental Research Funds for the Central Universities, the higher school specialized research fund for the doctoral program (222201313005 and 222201314029), 111 Project Grant (B08021), the Open Project of State Key Laboratory of Chemical Engineering (SKL-ChE-14C01), and Innovation Program of Shanghai Municipal Education Commission (15ZZ030).

语种：英文

外文关键词：FeAg bimetallic; Graphene; Antibacterial activity; Reactive oxygen species; GSH oxidation

摘要：We report the simple one pot synthesis of iron-silver (FeAg) bimetallic nanoparticles with different compositions on graphene support. The nanoparticles are well dispersed on the graphene sheet as revealed by the TEM, XRD, and Raman spectra. The antibacterial activity of graphene-FeAg nanocomposite (NC) towards Bacillus subtilis, Escherichia coli, and Staphylococcus aureus was investigated by colony counting method. Graphene-FeAg NC demonstrates excellent antibacterial activity as compared to FeAg bimetallic without graphene. To understand the antibacterial mechanism of the NC, oxidative stress caused by reactive oxygen species (ROS) and the glutathione (GSH) oxidation were investigated in the system. It has been observed that ROS production and GSH oxidation are concentration dependent while the increase in silver content up to 50% generally enhances the ROS production while ROS decreases on further increase in silver content. Graphene loaded FeAg NC demonstrates higher GSH oxidation capacity than bare FeAg bimetallic nanocomposite. The mechanism study suggests that the antibacterial activity is probably due to membrane and oxidative stress produced by the nanocomposites. The possible antibacterial pathway mainly includes the non-ROS oxidative stress (GSH oxidation) while ROS play minor role. (C) 2016 Elsevier B.V. All rights reserved.