文献类型：期刊文献

英文题名：Materiobiomodulated ROS Therapy for De Novo Hair Growth

作者：Bai, Long[1,2];Wang, Yifei[1];Wang, Kun[1];Chen, Xiaoqian[3,4];Zhao, Yuzheng[3,4];Liu, Changsheng[1];Qu, Xue[1,4]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Shanghai Univ, Optogenet & Synthet Biol Interdisciplinary Res Ctr, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Shanghai 200444, Peoples R China

年份：2024

卷号：36

期号：21

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20240815605696);WOS:【SCI-EXPANDED(收录号:WOS:001169338400001)】；

基金：L.B., Y.W., and K.W. contributed equally to this work. This work was jointly supported by the National Natural Science Foundation of China (No.T2288102, 32171341, 31922041), the 111 project (B14018), the Excellent Academic Leader Project of Shanghai Science and Technology Committee (21XD1421100), Young Elite Scientist Sponsorship Program by China Association for Science and Technology yNO.YESS20230049).We would like to thank Prof. Yuzheng Zhao for kindly support of ROS probes.

语种：英文

外文关键词：hair growth; in situ intracellular delivery; microneedles; polydopamine; reactive oxygen species

摘要：Hair loss is characterized by the inability of hair follicles (HFs) to enter the telogen-anagen transition (TAT) and lack of de novo HFs. Current pharmaceutical therapies and surgical modalities have been largely limited to regulating hair regrowth efficiently without side effects and lacking treatment compliance. Here, this work proposes a materiobiomodulation therapy (MBMT), wherein polydopamine (PDA) nanoparticles with redox activity can be modulated to have a stoichiometric ROS (H2O2) donating ability. These nanoparticles can intracellularly deliver ROS with high-efficiency via the clathrin-dependent endocytosis process. Utilizing homozygote transgenic HyPerion (a genetically-encoded H2O2 biosensor) mice, this work also achieves in vivo dynamic monitoring of intracellular H2O2 elevation induced by ROS donators. Subcutaneous administration with ROS donators results in rapid onset of TAT and subsequent hair regrowth with a specific ROS "hormesis effect." Mechanistically, ROS activate beta-catenin-dependent Wnt signaling, upregulating hair follicle stem cell expression. This work further develops a microneedles patch for transdermal ROS delivery, demonstrating long-term, low-dose ROS release. Unlike photobiomodulation therapy (PBMT), MBMT requires no external stimuli, providing a convenient and efficient approach for clinical hair loss treatment. This material-HF communication implicates new avenues in HF-related diseases, achieving targeted ROS delivery with minimal side effects. This study presents a materiobiomodulation therapy using polydopamine nanoparticles for controlled ROS delivery in hair regrowth, utilizing Hyperion mice with an H2O2 biosensor for in vivo ROS monitoring and activation of beta-catenin dependent Wnt signaling in hair follicle stem cells, enabled by a microneedle patch for hair loss treatment. image