文献类型：期刊文献

英文题名：Two-dimensional borocarbonitrides nanosheets engineered sulfonated polyether sulfone microspheres as highly efficient and photothermally recyclable adsorbents for hemoperfusion

作者：Weng, Ruiyu[1];Zhang, Liangzhu[2];Cao, Yuanhang[1];Wang, Zhihua[1];Zhao, Cancan[3];Wang, Jiemin[1,7];Zhao, Changsheng[4,5,6,7]

机构：[1]Sichuan Univ, Coll Biomed Engn, Chengdu 610064, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Coll Stomatol, Natl Ctr Stomatol,Natl Clin Res Ctr Oral Dis,Shang, Shanghai, Peoples R China;[4]Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China;[5]Sichuan Univ, Sch Chem Engn, Chengdu 610065, Peoples R China;[6]Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China;[7]Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Peoples R China

年份：2023

卷号：463

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20231213745926);WOS:【SCI-EXPANDED(收录号:WOS:000951717000001)】；

基金：Acknowledgements This project was financially sponsored by National Natural Science Foundation of China (NSFC) (No. 52103178, 51903171, and 82001006) , Sixth Two-hundred Talent B plan of Sichuan University and the Science and Technology Project of Sichuan Province (Grant No. 2021YJ0188 and 2023NSFSC0997) and China Postdoctoral Science Foundation (2021M703145) .

语种：英文

外文关键词：Hemoperfusion; Uremic toxin removal; BCN nanosheets; Polyethersulfone; Photothermal recycling

摘要：Adsorbents, which can be used to directly eliminate uremic toxins from blood, are decisive for hemoperfusion that maintains human renal function. However, developing adsorbents with large adsorption capacity, excellent chemical stability, high hemocompatibility and good cyclicity for toxins is still challenging. Herein, we proposed a type of two-dimensional (2D) carbon materials-borocarbonitrides (BCN) nanosheets as a novel uremic toxin adsorbent for blood perfusion. Theoretical analysis firstly confirmed the stronger binding capacity of BCN layer towards small molecular toxins than that of graphene. To make it applicable for practical perfusion, BCN nanosheets engineered sulfonated polyether sulfone (SPES) microspheres (B-PES) are thus constructed. Through static adsorption, the B-PES-4 achieves effective toxin adsorption capacities of 26, 40 and 197 mg g-1 on creatinine, uric acid and bilirubin respectively, which are 550%, 508% and 1756% outperforming pure SPES microspheres. In addition, simulated perfusion experiments demonstrate a good toxin removal efficiency for the microspheres, for example, over 80% of bilirubin is removed at a high perfusion rate of 20 mL min-1. Moreover, the B-PES microspheres neither induce hemolysis and immunoreaction in the blood nor affect cell viability. As a proof of concept, the photothermal property of BCN nanosheets is innovatively exploited for fast-drying and efficient recycling of the used B-PES microspheres. These features, together with the reusability, blood and cell compatibility, make the platform highly promising for clinical blood purification and artificial kidney application.