文献类型：期刊文献

英文题名：N-Acetylcysteine-Capped TLQP21-Containing Au Nanocages Alleviate Depression in Mice

作者：Shi, Meng[1];Li, Xiangyu[1];Fan, Zhen[2,3];Wang, Yi[4];Li, Congcong[1];Ning, Yuanmeng[1];Ma, Yizhao[1];Sun, Min[2,5];Xia, Xiaohuan[1,2,6,7];Du, Jianzhong[2,3,5];Zheng, Jialin C.[1,2,6,7,8]

机构：[1]Tongji Univ, Tongji Hosp, Ctr Translat Neurodegenerat & Regenerat Therapy, Sch Med, Shanghai 200065, Peoples R China;[2]Tongji Univ, Translat Res Inst Brain & Brain Like Intelligence, Shanghai Peoples Hosp 4,Shanghai Key Lab Anesthesi, Clin Res Ctr Anesthesiol & Perioperat Med,Sch Med, Shanghai 200434, Peoples R China;[3]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[4]Tongji Univ, Shanghai Yangzhi Rehabil Hosp, Translat Res Ctr, Sch Med, Shanghai 201619, Peoples R China;[5]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[6]Tongji Univ, Shanghai East Hosp, Sch Med, State Key Lab Cardiol & Med Innovat Ctr, Shanghai 200120, Peoples R China;[7]Tongji Univ, Innovat Ctr Med Basic Res Brain Aging & Associated, Minist Educ, Shanghai 200330, Peoples R China;[8]Tongji Univ, Collaborat Innovat Ctr Brain Sci, Shanghai 200072, Peoples R China

年份：2025

卷号：19

期号：42

起止页码：37186

外文期刊名：ACS NANO

收录：;EI(收录号：20254419412096);WOS:【SCI-EXPANDED(收录号:WOS:001593100400001)】；

基金：This work was supported in part by research grants from the National Natural Science Foundation of China (No. 91949204 to J.C.Z., No. 22335005 to J.D., No. 82271477 to X.X., No. 22305177 to M.Sun.), Shanghai Science and Technology Rising Star Program (No. 23QA1408400 to Y.W.), Innovation Program of Shanghai Municipal Education Commission (No. 2023ZKZD28 to J.D.), International Scientific Collaboration Fund of Science and Technology Commission of Shanghai Municipality (No. 23520710900 to Z.F.), Shanghai Rising-Star Program Sailing program (No. 23YF1433000 to M.Sun.), Shanghai Rising-Star Program (No. 23YF1450300 to Y.M.), and Fundamental Research Funds for the Central Universities and Tongji University Original Basic Research Program (No. 22120220596 to X.X.). The graphical abstract and Figures a and a were created using BioRender.com.

语种：英文

外文关键词：major depressive disorder; Au nanocages; TLQP21; NAC; chronic unpredictable mild stress

摘要：Major depressive disorder (MDD) is the most prevalent neuropsychiatric disorder globally. Promising therapies for MDD are urgently needed due to the limited effectiveness, delayed efficacy, and non-negligible side effects of current treatments. Oxidative stress and neuroinflammation have been recognized as key contributors to MDD. Here, we developed an antioxidant N-acetylcysteine (NAC)-capped Au nanocage (TNNC) that entrapped VGF-derived peptide TLQP21 with neuro-immunomodulatory effects. Once internalized by cells suffering from oxidative stress, NAC was consumed, and TLQP21 was released from TNNC. TNNC administration alleviated MDD-like behaviors of the chronic unpredictable mild stress (CUMS)-exposed mice and effectively relieved oxidative stress in the brains. Moreover, TLQP21 in TNNC inhibits the activation, excessive synaptic pruning, and inflammatory responses of microglia through targeting the complement C1q receptor (C1qR) and complement C3a receptor 1 (C3aR1). This work provides a bioinspired strategy to target multiple pathogenic factors in one nanoparticle for the intervention of MDD and other diseases.