文献类型：期刊文献

中文题名：2-甲基-4-甲氧基苯基苯胺的合成

英文题名：Synthesis of N-Phenyl-2-methyl-4-methoxyaniline

作者：邱潇[1];姜佳俊[2];王幸宜[2];沈永嘉[1]

机构：[1]华东理工大学结构可控先进功能材料及其制备教育部重点实验室和精细化工研究所,上海200237;[2]华东理工大学化学系,上海200237

年份：2005

卷号：25

期号：5

起止页码：561

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家教育部博士点基金(No.20030251001)资助项目

语种：中文

中文关键词：2-甲基-4-甲氧基苯基苯胺;合成方法;乙酸;硫酸;邻硝基甲苯;Bamberger重排

外文关键词：o-nitrotoluene; Bamberger rearrangement; N-phenyl 2-methyl-4-methoxyaniline; synthesis

摘要：邻硝基甲苯在甲醇、乙酸和硫酸混合溶液中,在Pt/C的催化下发生氢化和Bamberger重排生成2-甲基-4-甲氧基苯胺.后者在Pd/C的存在下以苯酚为反应介质与环已酮缩合生成2-甲基-4-甲氧基苯基苯胺,反应总产率63.0%.文中给出了产物与中间产物的核磁共振氢谱和质谱,同时讨论了影响反应的因素.
Using Pt/C as a catalyst, the hydrogenation and Bamberger rearrangement of o-nitrotoluene was carried out in a solution consisting of methanol, sulfuric acid and acetic acid, to afford 2-methyl-4-methoxyaniline. The intermediate product was further reacted with cyclohexanone in the presence of Pd/C in phenol to form N-phenyl-2-methyl-4-methoxyaniline. The total yield is 63%. The product as well as intermediate was determined by H-1 NMR and MS spectra. The factors of affecting the reactions were also discussed.