文献类型：期刊文献

英文题名：Catalytic Asymmetric [3+2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles

作者：Zhang, Jian[1,2];Ni, Tao[1,2];Yang, Wu-Lin[1,2];Deng, Wei-Ping[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Zhejiang Normal Univ, Dept Chem, Minist Educ Adv Catalysis Mat, Key Lab, Jinhua 321004, Zhejiang, Peoples R China

年份：2020

卷号：22

期号：11

起止页码：4547

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000538848600095)】；

基金：This work was supported by the National Natural Science Foundation of China (21901072) and the China Postdoctoral Science Foundation (2019T120310). We greatly appreciate the Research Center of Analysis and Test of East China University of Science and Technology for the assistance with the HRMS and NMR analyses.

语种：英文

摘要：A catalytic asymmetric decarboxylative [3 + 2] annulation via indolyl copper-allenylidene amphiphilic intermediates has been developed. This protocol offers a straightforward method for the synthesis of biologically important pyrrolo[1,2-a]indoles bearing contiguous quaternary and tertiary stereogenic centers with excellent diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). In addition, the diversity-oriented synthesis of pyrrolo[1,2-a]indoles was achieved via versatile transformations of the alkyne-containing cycloadducts.