文献类型：期刊文献

英文题名：Bridging the Biotic-Abiotic Divide: Design Principles of Hydrogel Interfaces for Next-Generation Brain-Machine Implants

作者：Li, Yeyuan[1];He, Zirui[1,2,3];Chen, Xinye[1];Pan, Lina[1];Yu, Yuanman[1,2,3];Liu, Changsheng[1,3]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Technol, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai, Peoples R China

年份：2026

外文期刊名：ADVANCED MATERIALS TECHNOLOGIES

收录：;EI(收录号：20263221250264);Scopus(收录号：2-s2.0-105046471402);WOS:【SCI-EXPANDED(收录号:WOS:001839221100001)】；

基金：This work was supported by the National Key R&D Program of China (2024YFF0508604), the National Natural Science Foundation of China (No. 82472161), the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (No. JKVD1211002), the Fundamental Research Funds for the Central Universities (No. JKD01251839), and the Foundation of National Center for Translational Medicine (Shanghai) SHU Branch (No. SUITM-202502).

语种：英文

外文关键词：bio-interfaces; BMIs hydrogel design; long-term BMIs stability; neuro-electrode mechanical compliance

摘要：Brain-machine interfaces (BMIs), recognized as transformative technologies for restoring neural function and decoding intricate brain activity, have started to come to the fore. Despite these advancements, a significant disparity persists between traditional machines-constructed from hard, dry, inanimate materials-and soft, wet, living biological tissue. This incongruity gives rise to chronic in vivo immune responses and hindered transmission at the neural interface. Hydrogels, due to their mechanical and chemical resemblance to biological tissue, along with their flexibility and adjustability in property design, have emerged as optimal candidate materials for facilitating human-machine interaction. Recent approaches integrate hydrogels with tissue engineering to create a biologically active and/or cell-containing living layer at the tissue-device interface, enabling seamless biointegration and novel cell-mediated therapeutic prospects. In this review, we comprehensively summarize the functional modalities, design principles, and present and future applications of hydrogel interfaces in attaining human-machine integration.