文献类型：期刊文献

英文题名：Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity

作者：Zhu, Qiaosha[1];Qian, Yang[2];Yang, Ying[1];Wu, Weifeng[1];Xie, Jingli[1,3];Wei, Dongzhi[1,3]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, Dept Food Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Fudan Univ, Zhongshan Hosp, Dept Radiotherapy, Shanghai 200032, Peoples R China;[3]SCICB, Shanghai 200237, Peoples R China

年份：2016

卷号：24

期号：4

起止页码：746

外文期刊名：JOURNAL OF FOOD AND DRUG ANALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000387937100009)】；

基金：This work was supported by "Open Funding Project of the State Key Laboratory of Bioreactor Engineering" and "National Major Science and Technology Projects of China (No. 2012ZX09304009)".

语种：英文

外文关键词：carbonyl iron powder; iron deficiency anemia; iron supplements; subchronic toxicity

摘要：Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement. Copyright (C) 2016, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.