文献类型：期刊文献

英文题名：Preparation and In Vivo Biodistribution of Ultra-Small Superparamagnetic Iron Oxide Nanoparticles with High Magnetic Targeting Response

作者：Han, Xiaoyu[1];Yao, Pingping[1];Cheng, Chao[3];Yuan, Hongmin[4];Yang, Yuxiang[1,2];Ni, Chaoying[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA;[3]Second Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai 200237, Peoples R China;[4]Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Jilin, Peoples R China

年份：2018

卷号：18

期号：2

起止页码：879

外文期刊名：JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

收录：;EI(收录号：20174904512099);WOS:【SCI-EXPANDED(收录号:WOS:000426033000019)】；

基金：We are grateful for the financial support from the National Science Foundation of China (20971043), the Open Project Program of State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, and we are also grateful to the Analysis and Testing Center, Yangzhou University for help in sample characterization.

语种：英文

外文关键词：USPIO; Blocking Temperature; In Vitro Targeted Interception; In Vivo Bio-Distribution

摘要：The ultra-small superparamagnetic iron oxide (USPIO) particles with high saturation magnetization and good superparamagnetism were prepared by reverse micro-emulsions using novel C16E15 as surfactant, which can reduce magnetic dipole-dipole interaction, hence decreasing the critical blocking temperature (T-B). Powder X-ray diffraction (XRD), Infrared spectrum (FT-IR), Transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), and Vibrating sample magnetometer (VSM) were used to characterize the magnetic particles. The higher ratio of Fe2+/Fe3+ caused redundant FeO on the USPIO surface. An in vitro approach model for simulating target delivery of USPIO particles to sites of interest was developed to illustrate the relationship between magnetic fluid retention rate and pole distance. In vivo targeted interception and magnetic targeting bio-distribution of superparamagnetic particles were also investigated simultaneously. The results indicated that the USPIO had high ability for magnetic focusing in mimetic surrounding tissue surrounding blood vessels under the action of pulsed magnetic field. The USPIO nanoparticles will be fundamental in biomedical applications.