文献类型：期刊文献

中文题名：红霉素固定床溶剂萃取法提取的研究

英文题名：Fixed-bed Solvent Extraction of Erythromycin

作者：曹正芳[1];乐清华[2]

机构：[1]华东理工大学石油化工学院,上海201512;[2]华东理工大学化工学院,上海200237

年份：2001

卷号：32

期号：8

起止页码：349

中文期刊名：中国医药工业杂志

外文期刊名：Chinese Journal of Pharmaceuticals

收录：CSTPCD;;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：红霉素;萃取;固定床;生物分离

外文关键词：erythromycin; extraction; the fixed bed solvent extraction; separation

摘要：采用固定床溶剂萃取技术提取发酵滤液中的红霉素 ,探讨了各因素对分离过程的影响。结果表明 ,该法可有效克服乳化 ,减少红霉素和溶剂的损失。在相比 (o/w)为 1/2 5时 ,萃取率可达 95 %左右 ,而传统溶媒萃取法的相比为 1/1时才能达到同效。采用纯溶剂作为洗脱剂 ,洗脱率达到 95 %
Fixed bed solvent extraction technology was developed for extracting erythromycin from its fermentation liquid, and various effects on the separation process were studied experimentally. The results showed that with the phase ratio of fermentation liquid to solvent 25∶1, the extraction rate was about 95% in weight, which was nearly equal to the value of traditional solvent extraction with the phase ratio of 1∶1. By adopting pure solvent as back extractant, the re extraction rate could also reach 95% in weight.