文献类型：期刊文献

英文题名：Self-assembly of pH-sensitive mixed micelles based on linear and star copolymers for drug delivery

作者：Huang, Xiujuan[1];Xiao, Yan[1];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2011

卷号：364

期号：1

起止页码：92

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20113914384489);WOS:【SCI-EXPANDED(收录号:WOS:000296038600013)】；

基金：This research was supported by the Fundamental Research Funds for the Central Universities (WD0913008, WD1014017), "Shu Guang" Project of Shanghai Municipal Education Commission, Shanghai Leading Academic Discipline Project (B502), Shanghai Key Laboratory Project (08DZ2230500), Natural Science Foundation of Shanghai (11ZR1409200), and Changjiang Scholars and Innovative Research Team in University (IRT0825).

语种：英文

外文关键词：Mixed micelles; pH-Sensitivity; Star copolymer; Self-assembly; Drug release

摘要：Comicellization of a star block copolymer poly(epsilon-caprolactone)-block-poly(diethylamino)ethyl methacrylate (S(PCL-b-PDEAEMA)) and a linear block copolymer methoxy poly(ethylene glycol)-block-poly(epsilon-caprolactone) (mPEG-b-PCL) was developed to enhance the stability and lower the cytotoxicity of the micelles. The two copolymers self-assembled into the mixed micelles with a common PCL core surrounded by a mixed PDEAEMA/mPEG shell in aqueous solution. This core-shell structure was transformed to the core-shell-corona structure at high pH due to the collapse of the PDEAEMA segment. The properties of the polymeric micelles were greatly dependent on the weight ratio of the two copolymers and the external pH. As increasing the mPEG-b-PCL content, the size and the zeta potential of the mixed micelles were lowered while the pH-dependent stability and the biocompatibility were improved. Moreover, an increase in pH accelerated the release of indomethacin (IND) from the mixed micelles in vitro. These results augured that the mixed micelles could be applied as a stable pH-sensitive release system. (C) 2011 Elsevier Inc. All rights reserved.