文献类型：期刊文献

英文题名：The synergistic effect of strontium-substituted hydroxyapatite and microRNA-21 on improving bone remodeling and osseointegration

作者：Geng, Zhen[1,2];Wang, Xiaogang[2];Zhao, Jin[1];Li, Zhaoyang[1];Ma, Lili[1];Zhu, Shengli[1];Liang, Yanqin[1];Cui, Zhenduo[1];He, Hongyan[2];Yang, Xianjin[1]

机构：[1]Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300350, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2018

卷号：6

期号：10

起止页码：2694

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20184005889337);WOS:【SCI-EXPANDED(收录号:WOS:000448405200015)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Grant No. 31570970 and 31570971), the Natural Science Foundation of Tianjin (Grant No. 17JCYBJC17500), and the National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002).

语种：英文

外文关键词：Physicochemical properties - Nanocapsules - Mineralogy - Composite coatings - Hydroxyapatite

摘要：Surgical failure, mainly caused by loosening implants, causes great mental and physical trauma to patients. As the population ages, improving the physicochemical properties of implants to achieve favourable osseointegration will continue to be the focus of future research. Herein, we fabricated a titanium (Ti)-based SrHA/miR-21 composite coating that was generated by hydrothermal deposition of SrHA followed by miR-21 nanocapsule immobilisation. Both SrHA nanoparticles with good superhydrophilicity and miR-21 nanocapsules with uniform sizes were distributed evenly on the surface of Ti. In vitro experiments revealed that the composite coating was beneficial for osteoblast proliferation, differentiation and mineralization. In vivo evaluations demonstrated that this coating could not only promote the expression of the angiogenic factor CD31 but also enhance the expression of osteoblastic genes to facilitate angio-osteogenesis. In addition, the composite coating also showed a decreased RANKL expression compared with the miR-21 coating. As a result, the SrHA/miR-21 composite coating promoted new bone formation and mineralization and thus enhanced osseointegration and bone-implant bonding strength. Therefore, this method provides a new strategy for bone repair.