文献类型：期刊文献

英文题名：Transition-metal-free synthesis of indolizines via [3+2]-annulation from α-bromoenals and 2-substituted azaarenes

作者：Liu, Yuan[1,2];Yu, Yang[1,2];Fu, Yiwei[1,2];Liu, Yonghai[1,2];Shi, Lei[3];Li, Hao[1,2];Wang, Wei[1,2,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Firmenich Aromat China Co Ltd, Corp R&D Div, Shanghai 201108, Peoples R China;[4]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2017

卷号：4

期号：11

起止页码：2119

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806137299);WOS:【SCI-EXPANDED(收录号:WOS:000413826400006)，CCR-EXPANDED(收录号:WOS:000413826400006)】；

基金：This work was supported by the National Natural Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and the China 111 Project (Grant B07023).

语种：英文

外文关键词：Addition reactions

摘要：A transition-metal-free synthetic approach to synthesize indolizines from alpha-bromo-substituted enals and simple 2-substituted azaarenes has been developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramolecular N-alkylation and aromatization were involved in this convergent and feasible "one-pot" tandem reaction to afford the annulation products in moderate to good yields.