文献类型：期刊文献

英文题名：Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins

作者：Xu, Lei[1];Liu, Lichao[1];Liu, Feng[1];Li, Wen[2];Chen, Ruobin[2];Gao, Yun[1];Zhang, Weian[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Coll Mat Sci & Engn, Dept Polymer Mat, Polymer Chem Lab, Shanghai 200444, Peoples R China

年份：2015

卷号：3

期号：15

起止页码：3062

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20151500740605);WOS:【SCI-EXPANDED(收录号:WOS:000352287400017)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 51173044), Research Innovation Program of SMEC (No. 14ZZ065), and Shanghai Pujiang Program under 14PJ1402600. W. Z. also acknowledges the support from the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Solutions - Light scattering - Photodynamic therapy - Sulfur compounds - Photosensitizers - Micelles - Ultraviolet visible spectroscopy

摘要：OEGylation of porphyrins via a disulfide linkage to form a novel class of dendritic porphyrin photosensitizers (PSs) is presented. These amphiphilic PSs possess precise molecular structures which could self-assemble into spherical aggregates in aqueous solutions. Their thermoresponsiveness was investigated using UV-Vis spectroscopy, and their reduction responsive properties were inspected using dynamic light scattering and TEM measurements. Moreover, the uptake of porphyrin-containing dendritic micelles by cells and release of reduction-sensitive PSs were investigated using flow cytometry and confocal laser scanning microscopy. The results showed that the cellular uptake of dendritic micelles was more than that of free porphyrin and the uptake process was time-dependent. Additionally, the phototoxicity of these dendritic PS micelles was investigated by MTT assay. It was found that dendritic micelles exhibited efficient phototoxicity to cancer cells while the free porphyrin had nearly no toxicity under light irradiation. All results indicate that these dendritic PSs are promising for photodynamic therapy.