文献类型：期刊文献

英文题名：Construction of 3-Azabicyclo[3.1.0]hexane Backbone by the Reaction of Allenes with Allylamines via Tandem Michael Addition and Copper-Mediated Oxidative Carbanion Cyclization

作者：Xu, Hui;Han, Teng;Luo, Xiaoyan[1];Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：39

期号：3

起止页码：666

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000640183200001)，CCR-EXPANDED(收录号:WOS:000640183200001)】；

基金：This work was financially supported by the Shanghai Comittee of Science and Technology (No. 17ZR1407600). We greatly appreciate the Research Center of Analysis and Test of East China University of Science and Technology for the assistance with the MS and NMR analysis.

语种：英文

外文关键词：Oxidative coupling; Allenes; Allylamine; 3-Azabicyclo[3,1,0]hexane; Miachel addition

摘要：Main observation and conclusion A facile synthetic method for the construction of 3-azabicyclo[3.1.0]hexane in the presence of copper catalyst system was developed. The reaction proceeds through Michael addition of allylamines with allenes followed by copper-mediated intramolecular oxidative carbanion 5-exo-trig radical cyclization, affording potential biologically active 3-azabicyclo[3.1.0]hexane derivatives in moderate to high yields (42%-85%). [GRAPHICS] .