文献类型：期刊文献

英文题名：A near-infrared colorimetric fluorescent chemodosimeter for the detection of glutathione in living cells

作者：Li, Meng[1];Wu, Xumeng[2,3];Wang, Yao[2,3];Li, Yongsheng[2,3];Zhu, Weihong[2,3];James, Tony D.[1,2,3]

机构：[1]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：50

期号：14

起止页码：1751

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000330045400035)】；

基金：T.D.J and M.L. are grateful for financial support from China Scholarship Council (CSC) and University of Bath Full Fees Scholarship. The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. W.H.Z. is grateful for financial support from the Oriental Scholarship, and the Fundamental Research Funds for the Central Universities (WK1013002). T.D.J thanks ECUST for a guest professorship. T.D.J. also thanks the Royal Society for support.

语种：英文

摘要：A novel near-infrared (NIR) and colorimetric fluorescent molecular probe based on a dicyanomethylene-4H-pyran chromophore for the selective detection of glutathione in living cells has been developed. The fluorescence OFF-ON switch is triggered by cleavage of the 2,4-dinitrobenzensulfonyl (DNBS) unit by the interaction with GSH.