文献类型：期刊文献

英文题名：Self-Amplified Photodynamic Therapy through the ¹O2-Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer

作者：Liu, Zhiyong[1];Cao, Tianye[2,3,4];Xue, Yudong[1];Li, Mengting[2,3];Wu, Mengsi[1];Engle, Jonathan W.[2,3];He, Qianjun[4];Cai, Weibo[2,3];Lan, Minbo[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA;[3]Univ Wisconsin, Dept Med Phys, Madison, WI 53706 USA;[4]Shenzhen Univ, Guangdong Prov Key Lab Biomed Measurements & Ultr, Natl Reg Key Technol Engn Lab Med Ultrasound, Sch Biomed Engn,Hlth Sci Ctr, 1066 Xueyuan Rd, Shenzhen 518060, Peoples R China

年份：2020

卷号：59

期号：9

起止页码：3711

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000510194100001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039 and 21875063).

语种：英文

外文关键词：block copolymer; drug delivery; photodynamic therapy; reactive oxygen species; self-amplification

摘要：Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non-selective release of photosensitizers still exist. Herein, we report a O-1(2)-responsive block copolymer (POEGMA-b-P(MAA-co-VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen (O-1(2)) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. The O-1(2)-responsiveness of POEGMA-b-P(MAA-co-VSPpaMA) block copolymer enabled the realization of self-amplified photodynamic therapy by the regulation of Ppa release using NIR illumination. This may provide a new insight into the design of precise PDT.