文献类型：期刊文献

中文题名：基于HDP模拟聚合物与利福平协同组合的口服脂质体治疗水产养殖细菌感染

英文题名：Liposome of a synergistic combination of HDP-mimicking polymer and rifampicin for treating bacterial infections in aquaculture via oral administration

作者：Yu, Haowen[2];Chen, Luhang[2];Wu, Yueming[1,2];Dai, Wenhui[2];Chen, Minzhang[2];Chen, Yuan[2];Liu, Longqiang[2];Wang, Jiangzhou[2];Huang, Xinqi[2];Chen, Kang[2];Liu, Runhui[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat,Minist Educ,Key Lab Ultraf, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Dept Biomat & Stem Cells, Suzhou 215163, Peoples R China

年份：2025

卷号：68

期号：4

起止页码：1259

外文期刊名：SCIENCE CHINA-MATERIALS

收录：;EI(收录号：20251118031696);WOS:【SCI-EXPANDED(收录号:WOS:001438934700001)】；

基金：This work was supported by the National Natural Science Foundation of China (T2325010, 52203162, 22075078), the National Key Research and Development Program of China (2022YFC2303100), the Fundamental Research Funds for the Central Universities (JKVD1241029, JKD01241701), and the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission). The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for assistance with characterization. The authors thank the staff members of the Mass Spectrometry System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China, for providing technical support and assistance in data collection and analysis. The authors also thank Figdraw (www.figdraw.com) for the assistance in creating Figure 1, Figure 5a and Table of contents.

语种：中文

外文关键词：liposomes; oral administration; aquaculture; synergistic combinations; Vibrio infections

摘要：The extensive use of antibiotics in high-density aquaculture has accelerated the emergence of antibiotic-resistant bacteria. The presence of antibiotics in water and soil, and their transmission through the food chain exacerbate the pressures associated with antibiotic resistance, posing a significant threat to human health. Despite this challenge and serious issue, effective alternatives to antibiotics remain lacking. In this study, we report a potent synergistic effect between an HDP-mimicking polymer, DLLys90-BLG10, and rifampicin against Vibrio species. This synergistic combination substantially reduces the required dosage of rifampicin, thereby mitigating the risk of antibiotic resistance development and the release of rifampicin into water and soil. Furthermore, we developed a cell-penetrating peptide-modified liposome system that can co-encapsulate DLLys90-BLG10 and rifampicin, which exerts potent antibacterial activity against Vibrio both in vitro and in vivo, while maintaining bio-compatibility. Additionally, oral administration of CPP-Lip@Syn showed effective control of Vibrio infections. This strategy opens new avenues in exploring antibiotic alternatives in aquaculture and implies potential applications in aquaculture.