文献类型：期刊文献

英文题名：Anti-mycobacterial natural products and mechanisms of action

作者：Han, Jianying[1];Liu, Xueting[2];Zhang, Lixin[2];Quinn, Ronald J.[1];Feng, Yunjiang[1]

机构：[1]Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：39

期号：1

起止页码：77

外文期刊名：NATURAL PRODUCT REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000669858400001)】；

基金：Jianying Han would like to acknowledge Griffith University for the provision of the PhD scholarships (GUPRS and GUIPRS).

语种：英文

摘要：Covering: up to June, 2020 Tuberculosis (TB) continues to be a major disease with high mortality and morbidity globally. Drug resistance and long duration of treatment make antituberculosis drug discovery more challenging. In this review, we summarize recent advances on anti-TB natural products (NPs) and their potential molecular targets in cell wall synthesis, protein production, energy generation, nucleic acid synthesis and other emerging areas. We highlight compounds with activity against drug-resistant TB, and reveal several novel targets including Mtb biotin synthase, ATP synthase, 1,4-dihydroxy-2-naphthoate prenyltransferase and biofilms. These anti-TB NPs and their targets could facilitate target-based screening and accelerate TB drug discovery.