文献类型：期刊文献

英文题名：Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters

作者：Chen, Jianzhong[1];Li, Feilong[3];Wang, Fang[3];Hu, Yawen[2];Zhang, Zhenfeng[2];Zhao, Min[3];Zhang, Wanbin[1,2]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：21

期号：22

起止页码：9060

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000497259500042)】；

基金：We would thank the National Natural Science Foundation of China (Nos. 21702134, 21620102003 and 21772119) and Science and Technology Commission of Shanghai Municipality (No. 17ZR1415200) for financial support. We thank the Instrumental Analysis Center of SJTU for characterization.

语种：英文

摘要：An efficient Pd(OAc)(2)-catalyzed asymmetric hydrogenation of alpha-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)(2), a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)(2) which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral alpha-arylglycine fragments are widely found in many chiral products and bioactive molecules.