文献类型：期刊文献

英文题名：Antibiotic residue and toxicity assessment of wastewater during the pharmaceutical production processes

作者：Xue, JiaJia[1,2];Lei, Dandan[1];Zhao, Xiumei[3];Hu, Yaru[1];Yao, Shijie[1];Lin, Kuangfei[1];Wang, Zejian[4];Cui, Changzheng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Environm Protect Key Lab Environm Stand, Shanghai 200237, Peoples R China;[3]Environm Protect Dept North China Pharmaceut Co L, Shijiazhuang 050015, Hebei, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：291

外文期刊名：CHEMOSPHERE

收录：;EI(收录号：20214711195370);WOS:【SCI-EXPANDED(收录号:WOS:000757979800006)】；

基金：This work was supported by the National Water Pollution Control and Management Technology Major Projects (No. 2017ZX07402003) and the Science and Technology Commission of Shanghai Municipality (No. 20dz1200800) and Shanghai Sailing Program (No. 21YF1409700) .

语种：英文

外文关键词：Antibiotic production wastewater; Antibiotic pollution; Biological acute toxicity; Vibrio fischeri; Daphnia magna

摘要：Various pollutants are released during pharmaceutical production processes, which is of great concern. Most studies have focused on the terminal treatment results of mixed pharmaceutical wastewater, and further research on wastewater from the production processes is required. This study investigated the wastewater quality indicators, residual antibiotics, and biological toxicity of the wastewater during the production process in a large pharmaceutical producing factory in Northern China. The wastewater contained numerous organic pollutants, with the chemical oxygen demand (COD) values ranging from 2.0 x 103 to 2.6 x 105 mg L-1 and the total nitrogen (TN) values ranging from 1.3 x 103 to 2.0 x 104 mg L-1. High concentrations of cephalexin and cefradine remained in the wastewater of the production workshop, with the highest concentration of cefradine reaching 1328 mg L-1. The wastewater from the oxidation and solvent recovery workshops was more toxic to Vibrio fischeri and Daphnia magna than that of other workshops. Moreover, the biological acute toxicity of wastewater was significantly correlated with the concentration of COD and TN (p < 0.01). This study provides new insights into the treatment of antibiotic production wastewater, illuminating the incomplete extraction of products and the significant risk posed by pharmaceutical wastewater to the environment.