文献类型：期刊文献

英文题名：Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition

作者：Zhu, Jiaqian[1];Yuan, Huihui[1];Zhang, Shunqi[1];Hao, Xiang[2];Lan, Minbo[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Suzhou Univ Sci & Technol, Sch Phys Sci & Technol, Suzhou, Peoples R China

年份：2022

卷号：139

期号：42

外文期刊名：JOURNAL OF APPLIED POLYMER SCIENCE

收录：;EI(收录号：20223312580022);WOS:【SCI-EXPANDED(收录号:WOS:000851514300001)】；

基金：This work was supported by the Science and Technology Commission of Shanghai Municipality (STCSM, 20520712500, 20392002300) and the Fundamental Research Funds for the Central Universities (50321102117022).

语种：英文

外文关键词：antibacterial; anti-fouling; hydrophilicity; polydopamine fast deposition; surface modification

摘要：Implanted medical devices are widely used in clinic for disease treatment, but they generally suffer from the bio-fouling problem which leads to the reduction of service life and loss of therapeutic effects. Herein, an eco-friendly method based on polydopamine (PDA) fast deposition is developed to construct anti-fouling and antibacterial surface on polyurethane (PU). The self-adhesive layer of PDA contributes to the formation of a platform with active sites for further antibacterial and hydrophilic modification. Polyhexamethylguanidine (PHMG) as antibacterial ingredient and chondroitin sulfate (CS) as hydrophilic component covalently bind on PDA platform, which successively helps to form PU-PDA/PHMG/CS. The resultant surface demonstrates the excellent property of anti-protein adsorption (96.8%), anti-bacterial ability (99.9%), and cell compatibility (95.0%), which would have great potential for medical application.