文献类型：期刊文献

英文题名：New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (ε-caprolactone)

作者：Ren, Fuzheng[1];Gao, Yuan[1];Chen, Jialei[2];Jing, Qiufang[1];Yu, Yan[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Pharm, Shanghai, Peoples R China

年份：2013

卷号：18

期号：3

起止页码：745

外文期刊名：PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000316072700025)】；

基金：The authors would like to thank the supports from the National S&T Major Project, China the Fundamental Research Funds for the Central Universities and the Shanghai Committee of Science and Technology. This work was financially supported by the National S&T Major Project, China (Grant 2011ZX09102-005-02), the Fundamental Research Funds for the Central Universities (Grant WK0913002), and the Shanghai Committee of Science and Technology (Grant 11DZ2260600). The authors report no conflicts of interest.

语种：英文

外文关键词：MPEG-b-PCL; nanoemulsion; Coenzyme Q(10); emulsification

摘要：The objective of the study is to prepare a new self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymers methoxy poly (ethylene glycol)-block-poly (epsilon-caprolactone) (MPEG-b-PCL) and to investigate the effect of MPEG-b-PCL on the characteristics of SNEDDS. MPEG-b-PCL was synthesized and characterized by H-1-NMR, IR and GPC. Various ratios of MPEG-b-PCL copolymers and Tween 80 were used as emulsifier to prepare the new SNEDDS. SNEDDS with high oil and low surfactant content forms a semi-solid gel at room temperature, which could be effectively sealed in soft or hard capsules. The mean droplet size of SNEDDS-generated nanoemulsions significantly decreased after the addition of diblock polymer and increased with increase of PCL chain in MPEG-b-PCL. The drug Coenzyme Q(10) (CoQ(10)) was chosen as the model compound in this study due to its insolubility in water. CoQ(10) from SNEDDS was rapidly dissolved regardless of the fluid condition.