文献类型：期刊文献

英文题名：Optical Regulation of GABA Receptor by Visible Light via Azobenzene-Phenylpyrazole

作者：Qiao, Zhi[1];Fu, Wen[1];Huang, Qiutang[2];Li, Zhong[1];Zhao, Chunqing[2];Shao, Xusheng[3,4]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Nanjing Agr Univ, Coll Plant Protect, Educ Minist, Key Lab Integrated Management Crop Dis & Pests, Nanjing 210095, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Frontier Sci Res Base Optogenet Techn Ce, Sch Pharm & Engn Res Ctr Pharmaceut Proc Chem, Shanghai, Peoples R China

年份：2022

卷号：70

期号：18

起止页码：5541

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20221912080634);WOS:【SCI-EXPANDED(收录号:WOS:000802050800006)】；

基金：This work was financially supported by the National Natural Science Foundation of China (nos. 21877039 and 32072441), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-02-E00037), and Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28).

语种：英文

外文关键词：photopharmacology; GABARs; azobenzene; phenylpyrazole; photoregulation

摘要：Photopharmacology provides superior temporal and spatial resolution for the study of biological functions of gamma-aminobutyric acid receptors (GABARs), and photopharmacology based on GABARs has significantly advanced the research of neurons and cells. Herein, we reported the azobenzene-phenylpyrazole (ABPs) for controlling the function of GABARs by light. The insecticidal activity of ABPs against Aedes albopictus larvae was different before and after light illumination. ABP3 (1 mu M) could induce depolarization of dorsal unpaired median neurons and enable the real-time photoregulation of mosquito larval behavior. An electrophysiological experiment indicated that ABP3 had different inhibitory effects on GABARs before and after illumination. ABPs realized optical control of GABARs utilizing visible light, providing valuable supplements to the existing GABAR photocontrol tools.