文献类型：期刊文献

英文题名：Programming the group behaviors of bacterial communities with synthetic cellular communication

作者：Kong, Wentao[1,2]; Celik, Venhar[1,2]; Liao, Chen[1,2]; Hua, Qiang[3]; Lu, Ting[1,2,4]

机构：[1] Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 W Springfield Avenue, Urbana, IL, 61801, United States; [2] Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 W Gregory Drive, Urbana, IL, 61801, United States; [3] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China; [4] Department of Physics, University of Illinois at Urbana-Champaign, 1110 W Green Street, Urbana, IL, 61801, United States

年份：2014

卷号：1

期号：1

外文期刊名：Bioresources and Bioprocessing

收录：EI(收录号：20224513079113)

语种：英文

外文关键词：Behavioral research - Cell engineering - Genes - Mobile telecommunication systems - Population statistics - Timing circuits

摘要：Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits. One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors. Because of the ubiquity of cell-cell interactions within bacterial communities, having an ability of engineering these circuits is vital to programming robust cellular behaviors. Here, we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits, including those for population density control, temporal synchronization, spatial organization, and ecosystem formation. We conclude by summarizing recent advances, outlining existing challenges, and discussing potential applications and future opportunities. ? 2014 Kong et al.