文献类型：期刊文献

英文题名：Preparation and application of peptide molecularly imprinted material based on mesoporous metal-organic framework

作者：Wang, Min[1];Zhang, Lingyi[1];Zhao, Yameng[1];Zhang, Weibing[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai, Peoples R China

年份：2021

卷号：224

外文期刊名：TALANTA

收录：;EI(收录号：20204409417696);WOS:【SCI-EXPANDED(收录号:WOS:000600787800011)】；

基金：We gratefully acknowledged the support of the National Natural Science Foundation of China (No. 21974045), the Science and Technology Commission of Shanghai Municipality (No. 19142201100) and the Fundamental Research Funds for the Central Universities (No. 50321102017022).

语种：英文

外文关键词：Molecularly imprinted material; Metal-organic framework; Peptides; Adsorption

摘要：In this study, a new molecularly imprinted material, MIP@UiO-66-NH2, was synthesized with glutathione (GSH) as template and mesoporous metal organic framework (UiO-66-NH2) as matrix. The molecularly imprinted polymer was modified on the surface and into the pores of the UiO-66-NH2 by surface molecular imprinting method with thin polymer layer. Based on high specific surface area (1091.93 m(2) g(-1)) and appropriate pore size (35 nm) of the ordered mesoporous UiO-66-NH2, the adsorption capacity for GSH reached 94.43 mg g(-1), and the adsorption equilibrium could be achieved within 30 min. The adsorption isotherm data of MIP@UiO-66-NH2 could be described well by Freundlich model and the kinetic data complied well with pseudo-second-order model. In addition, the MIP@UiO-66-NH2 showed low adsorption capacity to GSH structural analogs (Q(L-cys) = 6.51 mg g(-1)), suggesting great selectivity for GSH recognition. Finally, the MIP@UiO-66-NH2 was successfully applied for selective separation of GSH from BSA, skim milk and egg white tryptic digest.