文献类型：期刊文献

英文题名：Albumin Corona-Coated Nanoscale Metal-Organic Framework for Enzyme-Mediated Cascade Metabolization of Uric Acid in Hyperuricemia

作者：Lv, Mingchen[1];Xu, Jiaxi[1];Chen, Ran[1];Hu, Wei[1];Zhou, Yuxiao[2];Sun, Min[2,3];Fan, Zhen[1,2];Du, Jianzhong[1,2,3]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[2]Tongji Univ, Clin Res Ctr Anesthesiol & Perioperat Med, Dept Gynaecol & Obstet, Shanghai Key Lab Anesthesiol & Brain Funct Modulat, Shanghai 200434, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：21

期号：14

外文期刊名：SMALL

收录：;EI(收录号：20251118022255);WOS:【SCI-EXPANDED(收录号:WOS:001464494500036)】；

基金：This research was supported by National Natural Science Foundation of China (52222306, 22075212, 22335005, and 22305177), international scientific collaboration fund of Science and Technology Commission of Shanghai Municipality (23520710900), Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28), and Shanghai Rising-Star Program (Sailing, 23YF1433000). The authors thank Dr. Erik Jan Cornel's (Ph.D. from University of Sheffield, UK) for help check and revise the whole manuscript. J.D. is the recipient of National Science Fund for Distinguished Young Scholars.

语种：英文

外文关键词：cascade reaction; hyperuricemia; metal-organic framework; protein corona; uricase

摘要：Hyperuricemia, characterized by elevated uric acid levels, is the primary cause of gout. Recombinant uricase is one of the last-resort therapies but generates unwanted pro-inflammatory H2O2 and anti-uricase antibodies. In this work, we developed an albumin corona-coated enzyme-loaded zeolitic imidazolate framework (UCZIF) to sustainably maintain low blood uric acid level without producing H2O2. The corona coating not only preserves loaded enzymes but also reduces macrophage phagocytosis by 73.4% compared to free uricase. In addition, the uptake level of UCZIF by dendritic cells is reduced by 74.1%, and the maturation of dendritic cells is inhibited by 35.4% compared to free uricase. Animal experiments demonstrate that albumin corona-coated UCZIF effectively lowers blood uric acid level in both acute and diet-induced chronic hyperuricemia models with significantly increasing the half-life of uricase. Furthermore, compared to the generation of anti-uricase antibodies during standalone uricase treatment, the levels of anti-uricase immunoglobulins are significantly reduced by 65.5% (immunoglobulin M) and 76.3% (immunoglobulin G) with repeated administration of albumin corona-coated UCZIF. Overall, this albumin corona-coated nanoscale metal-organic framework offers a promising approach to minimize the immunogenicity induced by exogenous enzymes and further safely reduce uric acid levels in the treatment of hyperuricemia.