文献类型：期刊文献

英文题名：Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

作者：Zhang, Yifan[1];Wan, Yilin[1];Liao, Yunyan[1];Hu, Yanjie[3];Jiang, Tao[2];He, Ting[1];Bi, Wei[3];Lin, Jing[1];Gong, Peng[4];Tang, Longhua[2];Huang, Peng[1]

机构：[1]Shenzhen Univ, Marshall Lab Biomed Engn, Int Canc Ctr, LET,Sch Biomed Engn,Hlth Sci Ctr, Shenzhen 518060, Peoples R China;[2]Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[4]Shenzhen Univ, Gen Hosp, Dept Gen Surg, Shenzhen 518055, Peoples R China

年份：2020

卷号：65

期号：7

起止页码：564

外文期刊名：SCIENCE BULLETIN

收录：;EI(收录号：20200408086449);WOS:【SCI-EXPANDED(收录号:WOS:000521734100010)】；

基金：This work was supported by the National Key Research and Development Program of China (2018YFA0704003), the Basic Research Program of Shenzhen (JCYJ20180305163452667, JCYJ20180507182413022, and JCYJ20170412111100742), the National Natural Science Foundation of China (81903564, 31771036, 51703132, and 21874119), the Guangdong Provincial Natural Science Foundation of Major Basic Research and Cultivation Project (2018B030308003), and the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China (161032). We thank Instrumental Analysis Center of Shenzhen University (Lihu Campus).

语种：英文

外文关键词：Synergistic therapy; Janus nanoparticles; Glucose oxidase; Fenton-like reaction; Theranostics

摘要：Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, Janus-type gamma-Fe2O3/SiO2 nanoparticles (JFSNs) are conjugated with glucose oxidase (GOx) for synergistic cancer starvation/chemodynamic therapy. The gamma-Fe2O3 hemisphere of JFSNs can perform photoacoustic/T-2 magnetic resonance dual-modal imaging of tumors. GOx on the surface of JFSNs catalyzes the decomposition of glucose and produces H2O2 for cancer starvation therapy. Subsequently, the gamma-Fe2O3 hemisphere catalyzes the disproportionation of H2O2 to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the gamma-Fe2O3 hemisphere and its substrate H2O2, thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2O2 and hydroxyl radicals significantly suppresses 4T1 mammary tumor growth with minimal adverse effects. (C) 2020 Science China Press. Published by Elsevier B.V. and Science China Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).