文献类型：期刊文献

英文题名：Highly enantioselective Michael addition of acetone to nitroolefins catalyzed by chiral bifunctional primary amine-thiourea catalysts with acetic acid

作者：Gu, Qing;Guo, Xing-Tao;Wu, Xin-Yan[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2009

卷号：65

期号：27

起止页码：5265

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000267587600017)，CCR-EXPANDED(收录号:WOS:000267587600017)】；

基金：We thank the National Natural Science Foundation of China (20402004, 20772029) and New Century Excellent Talents in University (NCET-07-0286) for financial support.

语种：英文

摘要：Highly enantioselective Michael reaction of acetone with a variety of nitroolefins catalyzed by N-[(1R,2R)-2-aminocyclohexyl]-N'-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-)-thiourea (1b) together with acetic acid is described. The Michael addition products were obtained in high yields (76-94%) and Lip to 96% ee. (C) 2009 Elsevier Ltd. All rights reserved.