文献类型：期刊文献

英文题名：Multicomponent Reactions Based on Fluoro-Containing Building Blocks

作者：Wu, Jingjing[1];Cao, Song[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Ctr Fluorine Chem Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2009

卷号：13

期号：18

起止页码：1791

外文期刊名：CURRENT ORGANIC CHEMISTRY

收录：;EI(收录号：20241916062266);WOS:【SCI-EXPANDED(收录号:WOS:000271391400004)】；

基金：Financially supports from the National High Technology Research and Development Program of China (863 Program, 2006AA10A201), the Shanghai Foundation of Science of Technology (073919107), Shanghai Leading Academic Discipline Project (B507), National Key Project for Basic Research (973 Project, 2007BAQ03771), and the Shanghai Education Commission are kindly acknowledged.

语种：英文

外文关键词：Crop protection - Lead compounds - Molecules

摘要：Fluorinated compounds play a unique role in the development of novel lead compounds in both medicinal chemistry and modern crop protection. The introduction of fluorine atom always produces significant changes in the physical properties and often improves the biological activity of target moleculars. Multicomponent reactions (MCRs) are becoming a vastly more powerful tool for the creation of molecule libraries due to their highly convergent diversity, efficiency, selectivity, and atom economy. This paper reviewed growing applications of the trifluoromethyl, difluoromethyl, and fluoroalkyl building blocks as one of components in the multicomponent reactions for the construction of complex and diverse fluorinated molecules, respectively.