文献类型：期刊文献

中文题名：Fabrication of shish-kebab-structured carbon nanotube/poly(ε-caprolactone) composite nanofibers for potential tissue engineering applications

英文题名：Fabrication of shish-kebab-structured carbon nanotube/poly(ε-caprolactone) composite nanofibers for potential tissue engineering applications

作者：Tong Wu[1,2,3];Xin Chen[1,2,3];Jin Sha[1,2];Yi-Yan Peng[3];Yu-Lu Ma[1,2];Lin-Sheng Xie[1,2];Lih-Sheng Turng[3]

机构：[1]Engineering Center of Efficient Green Process Equipment and Energy Conservation, Ministry of Education, East China University of Science and Technology;[2]School of Mechanical and Power Engineering, East China University of Science and Technology;[3]Wisconsin Institute for Discovery, University of Wisconsin-Madison

年份：2019

卷号：38

期号：1

起止页码：64

中文期刊名：Rare Metals

外文期刊名：稀有金属（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

基金：financially supported by the Fundamental Research Funds for the Central Universities (No. 22A201514030);China Postdoctoral Science Foundation (No. 2015M571504);the National Natural Science Foundation of China (Nos. 51503065 and 51273065);the Wisconsin Institute for Discovery in University of Wisconsin-Madison;China Scholarship Council

语种：英文

中文关键词：Carbon;nanotubes;Poly(ε-caprolactone);Electrospinning;Shish-kebab;structure;Tissue;engineering

外文关键词：Carbon nanotubes;Poly(ε-caprolactone);Electrospinning;Shish-kebab structure;Tissue engineering

摘要：The electrospinning process was applied to fabricate the nanofibers of biodegradable poly(ε-caprolactone)(PCL) in which different contents of multiwalled carbon nanotubes(MWCNTs) were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts(MG-63 cells). The carbon nanotube(CNT) concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.
The electrospinning process was applied to fabricate the nanofibers of biodegradable poly(ε-caprolactone)(PCL) in which different contents of multiwalled carbon nanotubes(MWCNTs) were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts(MG-63 cells). The carbon nanotube(CNT) concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.