文献类型：期刊文献

英文题名：Host defense peptide-mimicking β-peptide polymer displaying strong antibacterial activity against cariogenic Streptococcus mutans

作者：Yang, Yi[1,2,3];Qian, Yuxin[4];Zhang, Mingxing[2,3];Hao, Shuang[1];Wang, Hui[5];Fan, Yongqiang[1,2];Liu, Runhui[4,6];Xu, Dake[2,3];Wang, Fuhui[2,3]

机构：[1]Northeastern Univ, Life & Hlth Sci, Shenyang 110819, Peoples R China;[2]Northeastern Univ, Shenyang Natl Lab Mat Sci, Shenyang 110819, Peoples R China;[3]Northeastern Univ, Electrobiomat Inst, Key Lab Anisotropy & Texture Mat, Minist Educ, Shenyang 110819, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[5]Liaoning Petrochem Univ, Sch Environm & Safety Engn, Fushun 113001, Peoples R China;[6]East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, Res Ctr Biomed Mat, Key Lab Ultrafine Mat,Sch Mat Sci & Engn,Minist E, Shanghai 200237, Peoples R China

年份：2023

卷号：133

起止页码：77

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20223012421254);WOS:【SCI-EXPANDED(收录号:WOS:000830901100006)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 51871050), the National Natural Science Foundation of China (No. U210 620 6), the Natural Science Foundation of Liaoning Province (No. 20180510041), the Liaoning Revitalization Talents Program (No. XLYC1907158), the General Project of Natural Science Foundation of Science and Technology Department of Liaoning Province (No. 2021-MS-308), and the Fundamental Research Funds for the Central Universities (No. N2120007).

语种：英文

外文关键词：beta-peptide polymers; Host defense peptide; S. mutans; RT-qPCR; Transcriptome

摘要：Cariogenic Streptococcus mutans (S. mutans ) is a leading cause of bacterial-induced oral diseases. Current strategies to kill bacteria based on Host defense peptide (HDP) mimicking polymers hold promise to treat oral bacterial infection. Here, we explore the impact of hydrophobic subunit and chain length variation on the antibacterial and antibiofilm activity of beta-peptide polymers. The physicochemical and biological properties, such as the toxicity, the antibacterial activity, and the effect on bacterial transcription of fi-peptide polymers, were systematically investigated with numerous techniques. The results exhibited that the optimal beta-peptide polymer has low toxicity towards human periodontal ligament fibroblasts, and beta-peptide polymers (especially P3) have more excellent antibacterial activity against S. mutans than metronidazole. In addition, beta-peptide polymers inhibited the reversible and irreversible bacterial adhesion during the formation of biofilms. The polymer can promote biofilm dispersion by decreasing the hydrophobicity of bacterial cells after adhering to cell surfaces. Analysis of the transcriptome for S. mutans treated with beta-peptide polymers demonstrated that beta-peptide polymers could reduce the cariogenicity of S. mutans by impacting the transcription of the energy and acid metabolism-related genes. beta-peptide polymers are promising antimicrobial agents in clinical dentistry due to their high antibacterial efficiency and low toxicity. (C) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.