文献类型：期刊文献

中文题名：电子顺磁共振对五种中草药抗氧化活性的研究

英文题名：Study on Antioxidant Activities of Traditional Chinese Medicines by Electron Paramagnetic Resonance Technique

作者：周丽芳[1];朱翔[1];赵红莉[1];蓝闽波[1,2];史新梅[2]

机构：[1]华东理工大学上海市功能性材料化学重点实验室;[2]华东理工大学分析测试中心,上海200237

年份：2014

卷号：26

期号：3

起止页码：318

中文期刊名：天然产物研究与开发

外文期刊名：Natural Product Research and Development

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：上海市科委纳米专项(12nm0501100)

语种：中文

中文关键词：电子顺磁共振;抗氧化活性;中草药;自由基

外文关键词：electron paramagnetic resonance; antioxidant activities ; traditional Chinese medicine; free radical

摘要：采用电子顺磁共振(EPR)技术,通过大黄、香青兰、香茅草、懈寄生和骆驼蓬子五种中草药对1,1-二苯基-2-苦基肼自由基(DPPH)、羟基自由基(·OH)和超氧阴离子自由基(O-·2)3种自由基清除能力大小的比较,研究了大黄等五种中草药抗氧化活性能力。这五种中草药对3种自由基均有一定的清除作用,其中大黄清除DPPH和超氧阴离子自由基的IC50小于0.5 mg/mL,清除羟基自由基的IC50=1.892 mg/mL。结果表明五种中草药中大黄的抗氧化活性能力最强,为中草药用于生物体的抗氧化应激研究提供依据。
In this study, electron paramagnetic resonance （EPR） technique was used to investigate the antioxidant activities of five traditional Chinese medicines （TCM）, including rhubarb ,Dracocephalum moldavica L. , lemongrass, mistletoe and seed of common peganum. The 1,1- diphenyl -2- picryl-hydrazyl radical （ DPPH）, hydroxyl free radical and superoxide anion free radicals scavenging abilities of the five studied TCMs were investigated. The results indicated that the five studied TCMs all showed scavenging abilities against three free radicals,in which rhubarb exhibited the strongest activities. Its IC50 of scavenging DPPH and superoxide anion free radical were all less than 0.5 mg/mL and the IC50 of scavenging hydroxyl free radical was 1. 892 mg/mL.