文献类型：期刊文献

英文题名：Mechanisms of antimicrobial peptides as characterized by solid-state NMR

作者：Han, Rong[1,2,3];Wang, Shenlin[1,2,3,4]

机构：[1]Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China;[2]Peking Univ, Beijing NMR Ctr, Beijing 100871, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

年份：2022

卷号：2

期号：2

起止页码：119

外文期刊名：MAGNETIC RESONANCE LETTERS

收录：EI(收录号：20241015702575);WOS:【ESCI(收录号:WOS:001225651400001)】；

基金：Acknowledgement This work was supported by the National Key Research and Development Program of the Ministry of Science and Tech- nology, People's Republic of China (contract number 2016YFA0501203) , the National Natural Science Foundation of China (21874004, 31470727) , the Interdisciplinary Medicine Seed Fund of Peking University, and the Fundamental Research Funds for the Central University.

语种：英文

外文关键词：Antimicrobial peptides (AMP); Solid-state NMR (SSNMR); Sample preparation; Antimicrobial mechanisms; Whole -cell NMR

摘要：Antimicrobial peptides (AMP) are small proteins that play critical roles in host defense against microbe invasion. Many AMPs disrupt the cellular membrane of microbe, while the mechanism of action of AMPs can be very sophisticated. Solid-state NMR (SSNMR) technique is powerful in characterizing the mechanism of AMPs in vivo and in vitro. This review summarizes the recent advance of SSNMR technique in AMP mechanisms characterization. We highlight the sample preparation approaches, the SSNMR spectroscopic methods, and a number of outstanding examples of AMP mechanisms elucidated via SSNMR spectroscopy. (c) 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY -NC -ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).